MovDisordV3, France, Analysis, bibRecord, 000229

Adverse Drug Reactions to Dopamine Agonists: A Comparative Study in the French Pharmacovigilance Database

Identifieur interne : 000229 ( France/Analysis ); précédent : 000228; suivant : 000230

Adverse Drug Reactions to Dopamine Agonists: A Comparative Study in the French Pharmacovigilance Database

Auteurs : Santiago Perez-Lloret [France] ; Emmanuelle Bondon-Guitton [France] ; Olivier Rascol [France] ; Jean-Louis Montastruc [France]

Source :

Movement disorders [ 0885-3185 ] ; 2010.

RBID : Pascal:10-0446307

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Stimulant dopaminergique, Etude comparative, Français, Pharmacovigilance, Base de données, Ropinirole, Pramipexole, Bromocriptine, Pergolide, Apomorphine.
Wicri :
- topic : Base de données.

English descriptors

KwdEn :
- Bromocriptine, Comparative study, Database, Dopamine agonist, French, Nervous system diseases, Pergolide, Pharmacovigilance, Pramipexole, Ropinirole.

Abstract

Pharmacodynamical differences between dopamine agonists (DAs) suggest differences in their adverse drug reactions (ADRs) profile. In this study, frequencies of ADR to DAs or levodopa reports in the French Pharmacovigilance Database were explored. Reports occurring between January 1, 1984 and December 31, 2008 were selected (2,189 for DAs and 1,315 for levodopa). The numbers of ADRs by system organ class were compared using ropinirole as a reference. Diurnal somnolence was less frequently reported with all DAs when compared with ropinirole (P < 0.001). Impulse control disorders (ICDs) were more frequently reported with pramipexole (P < 0.001). Significant difference was found among DAs in the frequency of confusion or disorientation (P < 0.001), nausea and vomiting (P < 0.05), or edemas (P < 0.001). No difference among DAs was observed in the frequency of hallucination or arterial hypotension ADR reports (P = 0.3 and P = 0.1). Pleural effusions were more frequently reported with pergolide or bromocriptine (P < 0.001). Somnolence or ICD reports were less frequent with levodopa, whereas confusion was more frequently reported. In summary, our data show significant differences in the kind of ADRs reported for each DA.

Affiliations:

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Pascal:10-0446307

Le document en format XML

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<front><div type="abstract" xml:lang="en">Pharmacodynamical differences between dopamine agonists (DAs) suggest differences in their adverse drug reactions (ADRs) profile. In this study, frequencies of ADR to DAs or levodopa reports in the French Pharmacovigilance Database were explored. Reports occurring between January 1, 1984 and December 31, 2008 were selected (2,189 for DAs and 1,315 for levodopa). The numbers of ADRs by system organ class were compared using ropinirole as a reference. Diurnal somnolence was less frequently reported with all DAs when compared with ropinirole (P < 0.001). Impulse control disorders (ICDs) were more frequently reported with pramipexole (P < 0.001). Significant difference was found among DAs in the frequency of confusion or disorientation (P < 0.001), nausea and vomiting (P < 0.05), or edemas (P < 0.001). No difference among DAs was observed in the frequency of hallucination or arterial hypotension ADR reports (P = 0.3 and P = 0.1). Pleural effusions were more frequently reported with pergolide or bromocriptine (P < 0.001). Somnolence or ICD reports were less frequent with levodopa, whereas confusion was more frequently reported. In summary, our data show significant differences in the kind of ADRs reported for each DA.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Adverse Drug Reactions to Dopamine Agonists: A Comparative Study in the French Pharmacovigilance Database

Adverse Drug Reactions to Dopamine Agonists: A Comparative Study in the French Pharmacovigilance Database

Source :

Descripteurs français

English descriptors

Abstract

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